Special Session 24: Mathematical Problems in Cancer Research

نویسنده

  • Thierry Colin
چکیده

Hematopoiesis is a complex biological process that leads to the production and regulation of blood cells. It is based upon differentiation of stem cells. This process sometimes exhibits abnormalities in blood cells production, causing the so-called dynamical hematological diseases. A severe hematological disease is Chronic Myelogenous Leukemia (CML), a cancer of white blood cells. In some cases, Chronic Myelogenous Leukemia exhibits periodic oscillations in all blood cell counts, with periods falling in the range of 30-110 days, but usually about 70-80 days. In this work, we present a model of hematopoiesis dynamics. We analyze the asymptotic stability of the steady states and we numerically illustrate our results and obtain very rich dynamics of our model that we relate to observations of periodic chronic myelogenous leukemia.

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تاریخ انتشار 2008